Yersinia associated arthritis in SHR rats: effect of the microbial status of the host.
نویسندگان
چکیده
Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.
منابع مشابه
Long term follow up of SHR rats with experimental yersinia associated arthritis.
One hundred and one SHR rats were injected intravenously with live Yersinia enterocolitica O:8. The rats were randomly divided into two groups consisting of 48 and 53 rats. The group of 48 rats was monitored for 245 days to establish the incidence and the clinical features of the arthritis. The remaining 53 rats were killed in groups of three to five rats at intervals from four to 245 days afte...
متن کاملDevelopment of an experimental animal model for reactive arthritis induced by Yersinia enterocolitica infection.
We attempted to induce experimental arthritis in rats by systematically testing the effect of Yersinia infections in five strains of rats, using the intragastric, intraperitoneal, and intravenous routes of inoculation. We observed that Lewis rats which were given 10(4) to 10(5) Yersinia enterocolitica WA organisms via the intravenous route consistently developed arthritis. The arthritis was mos...
متن کاملEffect of Losartan in Complete Freund’s Adjuvant –Induced Arthritis in Rats
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by joint infiltration and bone damage. The aim of the present study was to evaluate the beneficial effects of losartan in adjuvant-induced arthritis (AIA). Arthritis was induced in rats by subcutaneous injection of 0.2ml of Complete Freund’s adjuvant (CFA) in the planter surface of the hind paw. Arthritic rats were al...
متن کاملEffect of Losartan in Complete Freund’s Adjuvant –Induced Arthritis in Rats
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by joint infiltration and bone damage. The aim of the present study was to evaluate the beneficial effects of losartan in adjuvant-induced arthritis (AIA). Arthritis was induced in rats by subcutaneous injection of 0.2ml of Complete Freund’s adjuvant (CFA) in the planter surface of the hind paw. Arthritic rats were al...
متن کاملStudy on anti inflammatory effect of scorpion (Mesobuthus eupeus) venom in adjuvant-induced arthritis in rats
Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints as well as other organs in the body. Adjuvant-induced arthritis models in inbred rats serve as relevant models for RA, having many clinical similarities to this disease. Using honey bee venom as a treatment for Rheumatoid arthritis is an ancient therapy in various parts of the world. However scorpion ve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 52 3 شماره
صفحات -
تاریخ انتشار 1993